610 Crystallization Process Development


Description:
Crystallization is an industrially important unit operation for isolation and purification of a wide range of chemical products, including pharmaceuticals and fine chemicals. Developing a crystallization process can be challenging, often complicated by multiple components and requirements that the solids are consistently isolated in the desired polymorphic forms, compounds, adducts, or solvates. Control of particle size distribution may be needed to avoid difficult filtrations or high impurity content. This session welcomes contributions related to theoretical as well as practical approaches to crystallization process development, including techniques and tools that can lead to more efficient development of robust crystallization processes. Case studies and examples of how commercial crystallization processes are developed, and papers which describe the design and operation of batch or continuous crystallization processes are particularly encouraged.

Sponsor:
Crystallization and Evaporation
Co-Sponsor(s):
Particle Technology Forum (03), Process Research and Innovation (12A)


Chair:
Thomas Vetter
Prof.
University of Manchester
School of Chemical Engineering and Analytical Science
Oxford Road
Manchester
Email: thomas.vetter@manchester.ac.uk

Co-Chair:
Bruce D. Hook
Fellow
The Dow Chemical Company
B-4810, 2301 N. Brazosport Blvd.
Lake Jackson, TX
77541
Fax Number: 979-238-0264
Email: BDHook@dow.com


Papers:
From Batch to Continuous Reactive Crystallization: A Case Study on Beta-Lactam Antibiotics
Matthew A. McDonald, Georgia Institute of Technology; Andreas S. Bommarius, Georgia Institute of Technology; Martha A. Grover, Georgia Institute of Technology; Ronald W. Rousseau, Georgia Institute of Technology
Crystallization Process Development of Large Size TMP Crystals
Qing Lu, Heibei university of Technolgy; Hua Sun, Hebei University of Science and Technology; Min Su, Hebei University of Technology
Polymorph Selection in Continuous Crystallizers in the Presence of Wet Milling
Yang Li, Tianjin University; Thomas Vetter, University of Manchester
Polymorph Dynamics of 2-Aminobenzoic Acid System in Continuous Oscillatory Baffled Crystallizer
Shivani Kshirsagar, Purdue University; Zoltan K. Nagy, Purdue University
Imaging Crystallization Using Deep Learning to Quantitatively Track the Polymorphic Transformation of Carbamazepine
Zhenguo Gao, Collaborative Innovation Center of Chemical Science and Engineering; Yuanyi Wu, Western University; Junbo Gong, Tianjin University; Ying Bao, Collaborative Innovation Center of Chemical Science and Engineering; Jingkang Wang, Tianjin University; Sohrab Rohani, Western University
Abstract Submissions Closed
See more of this Group/Topical: Separations Division