513 Emerging Tools and Enabling Technologies in Synthetic Biology: Sensors and Actuators


Description:
Synthetic biology applies engineering principles to construct biological systems with unique and useful properties. The process of design and construction of these systems poses major challenges, owing to the complexity of biology. However, emerging tools have enabled the rapid construction of increasingly complex systems with predictable behaviors. This session will cover the development and application of these tools to the diverse topics of synthetic biology. Topics include, but are not limited to, DNA assembly, genetic circuit design and validation, modeling approaches, biomolecular breadboarding, synthetic regulation, cell-cell communication, RNA-based control schemes, and general understanding of biology that stems from design and construction of synthetic systems. Systems will span from in vitro experiments, viruses, diverse bacteria, and eukaryotes (yeast, mammalian cells, and plants). This session will focus particularly on the development of synthetic biology technology and approaches.

Sponsor:
Bioengineering


Co-chairs:
Nathan Crook
North Carolina State University

Email: nccrook@ncsu.edu

Kristin Adolfsen
Lead Strain Engineer
Enevolv
Boston, MA
Email: k.adolfsen@enevolv.com


Papers:
Synthetic Organelles Engineered from Phase-Separating Proteins
Benjamin S. Schuster, University of Pennsylvania; Ellen H. Reed, University of Pennsylvania; Holly Ramage, University of Pennsylvania; Matthew C. Good, University of Pennsylvania; Daniel A. Hammer, University of Pennsylvania
Engineering a Blue Light Inducible Spycatcher System (BLISS) As a Tool for the in Vitro Photo-Pattering of Proteins and Optically Controlled Intracellular Protein Activity
Emily Hartzell, University of Delaware; Justin Terr, University of Delaware; Wilfred Chen, University of Delaware
Sequence Specific Constraint-Based Modeling of E. coli Cell-Free Protein Synthesis
Michael Vilkhovoy, Cornell University; Jeffery D. Varner, Cornell University
Cell-Free Systems for Equipment-Free Quantitation of Micronutrients in Human Serum
Monica McNerney, Georgia Institute of Technology; Mark P. Styczynski, Georgia Institute of Technology
Profiling Protease Substrate Specificity with Yess-NGS
Carl A. Denard, University of Texas at Austin; Rasha Yaghi, University of Texas at Austin; Joseph Taft, University of Texas at Austin; Brent L. Iverson, Univ. of Texas
Continuous Evolution of Engineered Synthetic Auxotrophs for Industrial Application
Aditya M. Kunjapur, Harvard Medical School; Michael G. Napolitano, Harvard University; Max Schubert, Harvard Medical School; Evan Appleton, Harvard Medical School; Karen Noguera, Harvard Medical School; Daniel J. Mandell, GRO Biosciences; George M Church, Harvard Medical School
Dissecting the Genotype-to Phenotype Map in Eukaryotes: Molecular Determinants of Dominance, Heterosis, Pleiotropy, and Epistasis in Complex Traits
Christopher M. Jakobson, Stanford University School of Medicine; Richard She, Stanford University School of Medicine; Daniel F. Jarosz, Stanford University School of Medicine
Tuning Extracellular Electron Transfer to Control Polymer Synthesis
Christopher M. Dundas, University of Texas at Austin; Gang Fan, University of Texas at Austin; Austin J. Graham, University of Texas at Austin; Benjamin K. Keitz, The University of Texas at Austin
Abstract Submissions Closed
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division