619 Gene Regulation Engineering: Design Principles and Tool Development


Description:
The regulation of gene expression dictates virtually all cellular processes with broad applications in biotechnology, medicine and synthetic biology. Controlling these processes requires a detailed understanding of the underlying gene regulatory mechanisms as well as approaches to manipulate existing or engineered regulatory interactions. For this session, we invite high-quality presentations that improve our ability to understand, predict, and control all aspects of gene expression through the quantitative characterization of its many molecular interactions. In addition, presentations on the construction and application of gene regulatory systems will be considered. Potential topics include regulation of transcription, translation, RNA stability, RNA processing, and post-translational modification as well as work that combines multiple gene regulatory systems to generate engineered genetic networks. Presentations that address gene regulation in industrial and medically relevant organisms particularly are encouraged.

Sponsor:
Bioengineering


Chair:
Anushree Chatterjee
Assistant Professor
University of Colorado Boulder
Chemical and Biological Engineering
Boulder, CO
80303
Email: chatterjee@colorado.edu

Co-chairs:
Lauren Woodruff
Assistant Professor
University of Massachusetts Amherst
Chemical Engineering
Amherst, MA
Email: lwoodruff@umass.edu

Albert Keung
Assistant Professor
North Carolina State University
Chemical and Biomolecular Engineering
Raleigh, NC
Email: ajkeung@ncsu.edu


Papers:
Automated Design of Non-Repetitive Genetic Parts Using Non-Repetitive Parts Calculator and Its Application in Characterizing 4,350 Highly Non-Repetitive E.coli Promoters
Ayaan Hossain, Penn State University; Alexander Reis, Penn State University; Sean Halper, Penn State University; Daniel Cetnar, Penn State University; Howard Salis, Penns State University
CHAOS: A Novel Strategy for Restricting Bacterial Evolution By Inducing Epistatic Interactions
Peter Otoupal, University of Colorado Boulder; William Cordell, University of Colorado Boulder; Madeleine Sitton, University of Colorado Boulder; Vismaya Bachu, University of Colorado Boulder; Anushree Chatterjee, University of Colorado Boulder
Mapping the Operational Landscape of microRNAs in Synthetic Gene Circuits
Tyler Quarton, University of Texas at Dallas; Kristina Ehrhardt, The University of Texas at Dallas; James Lee, The University of Texas at Dallas; Yi Li, The University of Texas at Dallas; Leonidas Bleris, The University of Texas at Dallas
Enhancer-Mediated Dynamic Gene Control
Bomyi Lim, University of Pennsylvania; Yuji Yamazaki, Kansai Electric Power Medical Research Institute; Siddhartha Jena, Princeton University; Samuel Keller, University of Pennsylvania; Michael Levine, Princeton University
Developing a High Affinity, Dynamic Scaffold Toolkit for Intracellular Spatial Organization of Proteins
Alexander Mitkas, Universtiy of Delaware; Wilfred Chen, University of Delaware
Improving Phenotypes of Escherichia coli at the Post-Transcriptional Level By Engineering Poly(A) Polymerase I
Yinan Wu, Tsinghua University; Tongjun Xiang, Tsinghua University; Mei Li, Tsinghua University; Chong Zhang, Tsinghua University; Xin-hui Xing, Tsinghua University
Predicting Coupled Expression Dynamics in Bacterial Operons
Daniel Cetnar, Penn State University; Xun Tang, Penn State University; Howard Salis, Penns State University
Abstract Submissions Closed
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division