Yutaka Tomida, Aiichiro Nagaki, and Jun-ichi Yoshdia. Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan
The Br-Li exchange of p-, m-, and o-dibromobenzenes followed by reactions electrophiles using microflow systems can be conducted at much higher temperatures than those required for conventional macro batch systems. The sequential integration of the processes provides a straightforward method for the synthesis of a variety of disubstituted benzenes.