A Microfluidic Platform for University-Level Analytical Chemistry Laboratories

We demonstrate continuous flow acid-base titration reactions as an educational microfluidic platform for undergraduate and graduate analytical chemistry courses. A series of equations were developed for controlling and predicting the results of acid-base neutralization reactions conducted in a microfluidic format, including the combinations of (i) a strong base and a strong acid, (ii) a strong base and a weak acid, and (iii) a strong base and a multiprotic acid. Microfluidic titrations yielded excellent repeatability. The small experimental footprint is advantageous in crowded teaching laboratories, as it offers limited waste and exposure to potentially hazardous acids and bases. This platform will help promote the utilization of microfluidics at an earlier stage of students’ careers.