Carbamazepine dihydrate crystals are acicular in shape with a very large ratio of length to width. The crystals are very weak and hence frangible and readily undergo extensive attrition during isolation and drying after crystallisation. We explore and evaluate a simple and rapid method of assessing the breakage extent by the use of the aerodynamic disperser of ‘Malvern G3 Morphologi’. The shift in the crystal aspect ratio as a result of the impact breakage is quantified for various dispersion pressures using image analysis software of the instrument. The breakage extent obtained by the method is analysed and the mode of failure is identified. The results are compared with other more established impact-based method and will be presented.
Disclosures: Data were generated by University of Leeds. AbbVie Inc., North Chicago, USA, provided financial support for a studentship of Wei-Pin Goh. Kushal Sinha, Nandkishor Nere, Raimundo Ho, Shailendra Bordawekar and Ahmad Sheikh are present employees of AbbVie Inc.
See more of this Session: Particle Morphology, Size, Density and Surface Texture Characterization II
See more of this Group/Topical: Particle & Bulk Powder Characterization
See more of this Group/Topical: Particle & Bulk Powder Characterization