Image-guided therapy has become a substantially growing area of minimally invasive procedures. The gold standard of x ray guided percutaneous interventions such as biopsies or catheter based procedures interventions done in a cathlab is evolving to more sophisticated image control of devices for delivery of ablative energy, drugs, genes to diseased tissues. Advanced therapeutic imaging will be a core topic of future medical device development and clinical research. Thereby non-ionising radiation based imaging techniques (US Ultrasound  and MRI magnetic resonance imaging)  are key technologies for guiding and control of medical devices during  interventions and surgery.

 Ultrasound can not only been used for diagnostic imaging but also to influence cell membrane interactions, to release drugs or to destroy tissue. The applications of MRI guided therapy using focused ultrasound and other ablation techniques is unravelled to navigate to the target lesion and to monitor temperature responses and tissue destruction. The links between clinical diagnosing and treating cancers through technological innovations ranging from Sonography to Sonoporation with US and from nanoparticle based contrast enhanced molecular MR imaging to molecular oncology carry a great potential. Novel targeted drug delivery using nanospheres or lysosomes utilizing heat or electromagnetically activated drug release in the target volume of a tumour opens new opportunities for medical device design.