Jeju horse is a small-size race horse, and known as remarkable stamina and endurance native in Korea. In order to provide better understanding of the Korea native Jeju horse, we analyzed DNA methylation patterns of 20 different tissues including brain, heart, organs, and muscle by reduced representation bisulfite sequencing (RRBS) and MBD sequencing along with RNA sequencing. It is well known that DNA methylation, which is one of the major epigenetic mechanisms, plays essential role regulating gene expression. The analysis on global methylation signatures well reflected tissue specificity which may play an important role in tissue differentiation. In this study, we revealed DNA methylation and RNA-seq data relationship on tissue-specific gene expression, alternative splicing and differential methylation levels in Jeju horse.
