P1115
Exploring the Genetic Signature of Body Size in Yucatan Miniature Pig

Date: Monday, January 13, 2014
Room: Grand Exhibit Hall
Hyeongmin Kim , Seoul National University, Seoul, South Korea
Duk-Kyung Kim , Hankyong National University, Anseong, South Korea
Hyeon Jeong Kim , C&K Genomics, Seoul National University Research Park, Seoul, South Korea
WonCheoul Park , Seoul National University, Seoul, South Korea
Jaemin Kim , Seoul National University, Seoul, South Korea
Taeheon Lee , Seoul National University, Seoul, South Korea
Dong-Hyun Shin , Seoul National University, Seoul, South Korea
Woori Kwak , C&K Genomics, SNU Reseach Park, Seoul, South Korea
Young-jun Kwon , Seoul National University, Seoul, South Korea
Samsun Sung , C&K Genomics, Seoul National University Research Park, Seoul, South Korea
Sunjin Moon , Seoul National University, Seoul, South Korea
Tae-Hun Kim , National Institute of Animal Science, RDA, Suwon, South Korea
Kang Seok Seo , Sunchon National University, South Korea
Girak Kim , Seoul National University, Seoul, South Korea
Sungmoo Park , Seoul National University, Seoul, South Korea
Cheol-Heui Yun , Seoul National University, Seoul, South Korea
Hyunil Kim , Optipharm Inc, Cheongwon, South Korea
Jiho Kim , Optipharm Inc, Cheongwon, South Korea
Woon Kyu Lee , Inha University, Incheon, South Korea
Hong-Sik Kong , Hankyong National University, Anseong, South Korea
Jae-Don Oh , Hankyong National University, Anseong, South Korea
Eui-Soo Kim , Iowa State University, IA
Hak-Kyo Lee , Hankyong National University, Anseong, South Korea
Ki-Duk Song , Hankyong National University, Anseong, South Korea
Heebal Kim , Seoul National University, Seoul, South Korea
Seoae Cho , C&K Genomics, Seoul National University Research Park, Seoul, South Korea
Since being domesticated about 10,000 – 12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection and reveal layers of evolutionary history of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating FST based neighbor-joining tree and XP-EHH using re-sequencing data derived from 70 pigs, we were able to unravel the evolutionary layers of adaptation of body size. We found that in the ancient evolutionary history analyzed by FST, both adaptations at the level of organ and organism, and at the cellular level have occurred. Adaptions at the higher levels include feed intake, regulation of body weight and increase in mass while adaptation at the molecular level includes cell cycle. The recent selection probed by XP-EHH, suggest adaptations at the cellular level including cell growth and regulation of cell cycle.
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