W372
Functional Genomics Resources at EBI: ArrayExpress and Expression Atlas

Date: Sunday, January 11, 2015
Time: 10:15 AM
Room: California
Maria Keays , European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
Expression Atlas consists of pre-analyzed RNA-seq and expression microarray
data, to enable users to discover which genes are expressed in which tissues,
cell types, developmental stages, and hundreds of other experimental
conditions. This could be either in a baseline context, e.g. to find genes
expressed in the bovine kidney, or in a differential context, e.g. to find
genes that are upregulated in response to salt stress in rice. All datasets
are manually curated to a high standard, by our in-house curators and using
advice from experts around the world. At the time of writing, Expression Atlas
consists of 802 datasets, including 47 RNA-seq experiments. All data in
Expression Atlas is free to browse, download, and re-use. ArrayExpress is an
archive of functional genomics experiments, submitted by scientists working in
diverse fields. Submission to ArrayExpress is free of charge, and datasets can
be kept private until the submitter publishes their findings. Submission is
now quicker and easier than ever before, thanks to our new tool, Annotare:
most submissions are accessioned within 24 hours. ArrayExpress also imports
all new releases from NCBI GEO weekly.  As of October 2014, ArrayExpress
consists of 53782 datasets studying a wide variety of organisms, from cattle
and chicken to rice and maize. The majority of ArrayExpress data is microarray
based, though our RNA-seq coverage is growing daily. Public data in
ArrayExpress is freely available for download, either from the website or via
programmatic access. Both resources employ ontology-driven query expansion,
enabling powerful searching across thousands of datasets.