The Best Bones, Imputation and Ancient Genomics

High throughput sequencing technologies have rescued the field of ancient DNA from the cul de sac of haplotype typology and, in the main, from the problem of contamination. The challenges now are in taking the steps towards efficient and affordable whole genome coverage, particularly as sampling is destructive and may not be repeatable.  Data from animal and human aDNA projects will be discussed.  Particularly, bone choice and subsampling of of specific bones are key.  Even with excellent extracts, short fragments limit cost efficiency and often prohibit high coverage sequencing.  Imputation from lower genome coverage is a promising tool for leveraging limited data.