Large Scale Identification and Characterization of RNA Binding Protein-RNA Networks

RNA binding proteins (RBPs) play essential roles in cellular physiology by interacting with target RNA substrates. Elucidating the binding sites of RBPs is a crucial first step in deepening our understanding of RNA biology. I will present our ongoing efforts as part of the ENCODE consortium to define the binding sites at nucleotide-level resolution for hundreds of RNA binding proteins.