A Brief Introduction to the Workshop and My Research

The workshop would be a platform for scientists working to understand how genomic features affect the function of chromosomes. The eukaryotic genome is packed into chromosomes, which function regulation and interaction between DNA, RNA, and proteins. Chromosomes have two main functions: to ensure that the DNA is segregated equally to daughter nuclei at cell division, and to ensure that the integrity of the genome is maintained and accurately replicated in each cell cycle. The elements responsible for these functions are centromeres, telomeres and replication origins, respectively. Genome sequencing has been providing enormous materials to understand chromosome biology. From these precious materials, scientists are finding how genomic features, such as base composition, homoeologous or ectopic sequence similarity, distribution of tandem genes, recombination hotspot, etc, affect the transcription, expression, functional innovation, and concerted evolution of genes, and chromosomal rearrangement, chromosome number reduction, and even whole genome repatterning.