P0535
Genome-Wide Association Study for Female Fertility Traits in Canadian Holsteins

Aline R. Guarini , University of Guelph, Guelph, ON, Canada
Mehdi Sargolzaei , The Semex Alliance, Guelph, ON, Canada
Valdecy A R Cruz , University of Guelph, Guelph, ON, Brazil
Filippo Miglior , Canadian Dairy Network & University of Guelph, Guelph, ON, Canada
Flavio Schenkel , Centre for the Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada
A genome-wide association study (GWAS) was conducted using a single SNP regression model, including a polygenic term fitting the SNP based genomic relationship matrix, for female fertility traits in Canadian Holstein cattle. Estimated breeding values and genotypes from 6,575 bulls genotyped with Illumina Bovine SNP50 BeadChip were obtained from the Canadian Dairy Network. Genotypes were imputed to HD (~777k) using FImpute software and a reference population of 2,387 animals. Only the 29 bovine autosomes were considered in the analyses. Female fertility traits included: days from calving to first service, 56-day non-return rate, number of services per conception, and days from first service to conception. The identified significant SNPs were submitted to NGS-SNP for obtaining functional annotations and identifying nearby genes that might be causative using the Bos taurus UMD3.1 assembly. Evidence for presence of QTLs affecting fertility traits was observed on chromosomes 6, 7, 14, 17, 19, and 21. One genomic region showed evidence for pleiotropic QTL affecting three fertility traits.
Handouts
  • Poster PAG [ARG].pdf (1.4 MB)
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