Methods Data were drawn from the National Health and Aging Trends Study (NHATS) and the National Study of Caregiving (NSOC), yielding a sample of 1,457 caregiver-care recipient pairs. Caregiving intensity across three domains — daily activities, health-related tasks, and medical care — was assessed at Round 5 (2015), with sleep disruption, relationship quality, and depressive symptoms measured at Round 7 (2017). Structural equation modeling was used to test mediation and moderated mediation models, stratified by dementia status (no, possible, and probable dementia).
Results The sample was predominantly female (67% caregivers, 69% care recipients), with a mean caregiver age of 60.88 years. Over half of care recipients (53%) had no dementia, while 33% had probable dementia. Medical caregiving intensity was significantly associated with greater caregiver sleep disruption (b = 0.07, p = .003), which predicted higher depressive symptoms in both caregivers (b = 0.22, p < .001) and care recipients (b = 0.21, p < .001), demonstrating bidirectional pathways. Help with health-related activities was associated with less interrupted sleep for care recipients (b = 0.11, p = .005), which in turn predicted lower depression. Care recipient sleep disruption similarly predicted caregiver depression, revealing true interdependence between partners. Four significant indirect effects were identified: medical caregiving predicted caregiver depression via caregiver sleep (b = 0.02, 95% CI [0.01, 0.03]), and care recipient depression via caregiver sleep (b = 0.02, 95% CI [0.01, 0.03]). Relationship quality moderated the association between medical caregiving and depression (b = 0.11, p = .047), with low relationship quality amplifying depressive symptoms, an effect most pronounced in the possible dementia group (b = 0.43, p = .033). Patterns differed across dementia stages, with medical care driving sleep-depression pathways in probable dementia and daily assistance more salient in non-dementia caregiving.
Conclusions and Implications Sleep disruption and relationship quality are modifiable targets for intervention in dementia caregiving. Addressing sleep health in both partners, particularly when medical caregiving demands are high, and strengthening relational bonds early in the caregiving trajectory are critical for reducing depression risk. Stage-specific support services that match the evolving demands of dementia progression are essential for improving outcomes across the full caregiving partnership.
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