Methane is a potent greenhouse gas with a shorter atmospheric lifetime than CO2 but a stronger warming potential molecule for molecule. Concentrations of CH4 continue to increase at record levels in 2020, making it a critical component of pathways to mitigate climate change. This session highlights bottom-up and top-down integration of measurements and model simulations of methane sources and sinks. Examples of relevant topics include inventory, modeling or remote sensing methods to estimate wetland and freshwater emissions, sources from the agriculture and energy sectors, atmospheric (inverse) modeling and use of atmospheric isotopes or co-emitted tracers. The session also invites research on inter-annual and decadal scale trends and variability of methane sources and sinks. The research presented will contribute to an updated global methane budget being developed under the umbrella of the Global Carbon Project budget.