| Virus Engineering for Targeted Gene Delivery | ||
| Pin Wang1, Leslie Bailey2 and Kendra Rideout2, (1)Chemical Engineering and Material Science, University of Southern California, 925 Bloom Walk, HED-216, Los Angeles, CA 90089-1211, (2)Chemical Engineering, University of Southern California, 925 Bloom Walk, HED-216, Los Angeles, CA 90089-1211 We devised a new strategy to engineer nanoparticles for targeted gene delivery. The nanoparticles we deal with are viruses with the size of 100 nm. We found that recombinant viruses incorporated with membrane-bound antibodies can specifically infect cells expressing the cognate antigens. We have demonstrated that this general method worked for many antibodies and several cell types. Animal experiments have been designed to evaluate the efficacy of in vivo gene delivery using this method. Extended Abstract Status: Not Uploaded | ||