| Monitoring the Hydrolysis of Acetic Anhydride Using in-Situ Raman Spectroscopy and Novel Multivariate Data Analysis – Band-Target Entropy Minimization (Btem) | ||
| Effendi Widjaja, Process Science and Modeling, Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore, Ying Yan Tan, Department of Chemical & Biomolecular Engineering, National University of Singapore, Department of Chemical & Biomolecular Engineering, 4 Engineering Drive 4, Singapore, 117576, Singapore and Marc Garland, Process Science and Modeling, Department of Chemical & Biomolecular Engineering, Institute of Chemical and Engineering Sciences, National University of Singapore, Department of Chemical & Biomolecular Engineering, 4 Engineering Drive 4, Singapore, 117576, Singapore With the increasing demand for novel process analytical technologies in recent years, Raman spectroscopy has been one of the powerful choices for in-situ reaction monitoring. In this paper, we discuss the use of in-situ Raman spectroscopy and novel multivariate data analysis method namely band-target entropy minimization (BTEM) to monitor the hydrolysis of acetic anhydride to acetic acid. In-situ Raman spectroscopy is employed to continuously measure the spectrum of reaction mixture in every 2 minutes for a few hours time. The collected spectra are then subjected to BTEM in order to elucidate the pure component spectra and the concentration profiles of the observed components. In addition, a comparison study between univariate and multivariate data analysis on the reaction spectra is also presented. Extended Abstract Status: File Uploaded | ||