342646 Applications of Modeling and Simulating Moisture Profiles During Fluid Bed Granulation Process Development

Tuesday, November 5, 2013: 8:30 AM
Plaza A (Hilton)
Steve Mehrman, PDMS, Spring House, PA, John Cunningham, PDMS, Malvern, PA, Eric Sanchez, Janssen Pharmaseuticals, Gurabo, PR, Mauricio Futran, Janssen Pharmaceuticals, Raritan, NJ, Terry Murphy, PDMS, Cork, Ireland, James Weber, PDMS, Spring House, Adam Fermier, Janssen Pharmaceuticals, Spring House, PA, Ray Boucher, Real Time Power Inc., Switzerland and Andrew Skalkin, Janssen R&D US, Spring House, PA

Developing a robust fluid bed granulation process is often challenging due to a variety of equipment configurations and interrelated controls.  To overcome these challenges we have been developing first principal modeling and simulation tools focused on moisture control profiling.  Examples using these tools to model historical batch performance and simulation to design scale up and process DOE’s will be described.

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See more of this Session: Model Based Integrated Design of Pharmaceutical Drug Substance and Drug Product and Processes I
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum