511 Thermodynamics of Biomolecular Folding and Assembly


Description:
Biological systems require precise folding, recognition, and self-assembly behaviors to form complex nanostructures and molecular machines. This session solicits theoretical, simulation, and experimental studies that address aspects of both natural and synthetic biomolecule folding and assembly. We encourage submissions that focus on fundamental biophysical thermodynamic and transport properties, mechanisms, and models. Topics of interest include: protein, RNA, and DNA folding and stability; design of structure and function; biomolecules at interfaces and under confinement; and self-assembly of biomolecules into machines and materials.

Sponsor:
Thermodynamics and Transport Properties


Chair:
Sapna Sarupria
Assistant Professor
Clemson University
Department of Chemical and Biomolecular Engineering
Clemson, SC
29634
Email: ssarupr@g.clemson.edu

Co-Chair:
Andrew L. Ferguson
Assistant Professor
University of Illinois at Urbana-Champaign
Departments of Materials Science and Engineering and Chemical and Biomolecular Engineering
204 MSEB
Urbana, IL
61801
Email: alf@illinois.edu


Papers:
Computational Study of the Stability of the Miniprotein Trp-Cage in Extreme Environments
Betul Uralcan, Princeton University; Sang Beom Kim, Princeton University; Pablo G. Debenedetti, Princeton University
Engineering Robust Activity in Extremophilic Enzymes
Siva Dasetty, Clemson University; Weigao Wang, Clemson University; Mark Blenner, Clemson University; Sapna Sarupria, Clemson University
Towards a Thermodynamic Model for Predicting Coiled-Coil Protein Structures
Mojtaba Jokar, Wayne State University; Korosh Torabi, Wayne State University
Effect of Residual Secondary Structure Propensity on Liquid-Liquid Phase Separation of Tdp-43
Gregory L. Dignon, Lehigh University; Gul H. Zerze, Lehigh University; Nicolas Fawzi, Brown University; Young C. Kim, Naval Research Laboratory; Jeetain Mittal, Lehigh University
Solvation Contribution to the Conformational Preferences of the Hydrated Peptides
Gul H. Zerze, Lehigh University; Alexander Bourque, Massachusetts Institute of Technology; Jeetain Mittal, Lehigh University
Influence of Backbone Hydrogen Bonding on the Stability of the WW Domain of the Protein Pin1
Daniel Markthaler, University of Stuttgart; Niels Hansen, University of Stuttgart
Molecular Simulations of the Force Spectroscopy of a Biomimetic Polymer
Aviel Chaimovich, Max Planck Institute for Polymer Research; Christian Leitold, University of Vienna, Faculty of Physics; Christoph Dellago, University of Vienna, Faculty of Physics
Insights into the Binding of β-Wrapins to Amyloidogenic Proteins Using Simulations and Experiments
Asuka A. Orr, Texas A&M University; Michael M. Wördehoff, Heinrich-Heine-Universitaẗ Düsseldorf; Hamed Shaykhalishahi, Heinrich-Heine-Universitaẗ Düsseldorf; Ewa A. Mirecka, Heinrich-Heine-Universitaẗ Düsseldorf; Sai Vamshi R Jonnalagadda, Texas A&M University; Wolfgang Hoyer, Heinrich-Heine-Universitaẗ Düsseldorf; Phanourios Tamamis, Texas A&M University
Abstract Submissions Closed
See more of this Group/Topical: Engineering Sciences and Fundamentals