310 Solid Form Selection: Cocrystals, Salts, Solvates, Polymorphs, and Beyond


Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.

Sponsor:
Crystallization and Evaporation
Co-Sponsor(s):
Pharmaceuticals (15B), Pharmaceutical Discovery, Development and Manufacturing Forum (26)


Chair:
Fang Wang
Clover Crystallization

Phone Number: 650-619-9260
Email: fang.wang@CloverCrystallization.com

Co-Chair:
Meenesh R. Singh
Assistant Professor
University of Illinois at Chicago
Department of Chemical Engineering
Chicago, IL
Phone Number: 312-413-7673
Email: mrsingh@uic.edu


Papers:
Introductory Remarks
310a
A Novel Microfluidic Platform for Screening of Pharmaceutical Polymorphs Under Hydrodynamically-Controlled Crystallization Conditions
Paria Coliaie, University of Illinois at Chicago; Meenesh R. Singh, University of Illinois at Chicago
310b
Polymorphism in Drug Compounds By Controlling Fluid Dynamics during Crystallization
Stephanie Guthrie, University of Virginia; Gaurav Giri, University of Virginia
310g
Mechanism of Selective Co-Crystallization of Cresol Isomers with Urea
Na Wang, Tianjin University; Hongxun Hao, Tianjin University; Qiuxiang Yin, National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University; Baohong Hou, National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University; Meijing Zhang, Tianjin University
310d
Continuous Cocrystallization of Benzoic Acid and Isonicotinamide By Mixing-Induced Supersaturation: Exploring Opportunities between Reactive and Antisolvent Crystallization Concepts
Vaclav Svoboda, University of Strathclyde; Pól MacFhionnghaile, University of Strathclyde; John McGinty, CMAC; Lauren E. Connor, CMAC; Iain D.H. Oswald, University of Strathclyde; Jan Sefcik, University of Strathclyde
310e
A Multiscale Computational Method for Prediction of Polymorphs
Anish V. Dighe, University of Illinois at Chicago; Meenesh R. Singh, University of Illinois at Chicago
310f
Polymorph Selection By Continuous Precipitation
Thomas Farmer, University of California Santa Barbara; Sina Schiebel, Technical University of Munich; Bradley F. Chmelka, University of California, Santa Barbara; Michael F. Doherty, UC Santa Barbara
Concluding Remarks
Abstract Submissions Closed
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