537882 Rational Design of Glucose-Responsive Insulin Using Pharmacokinetic Modeling

Naveed Bakh1, Gili Bisker2, Michael A. Lee1, Xun Gong1, Abel B. Cortinas3, Robert Langer4, Daniel A. Anderson5, Zhen Gu6, Sanjoy Dutta7, Michael Weiss8 and Michael Strano1, (1)Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (2)Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, (3)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (4)Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, (5)Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, (6)Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, (7)JDRF, New York, NY, (8)Case Western Reserve University, Cleveland, OH