P519
A Survey of Potential Antiviral Targets for the Pacific Whiteleg Shrimp Litopenaeus vannamei from RNAseq Transcriptome

Date: Monday, January 13, 2014
Room: Grand Exhibit Hall
Rogerio Sotelo-Mundo , BioMolecular Structure Lab. CIAD Centro de Inv. en Alimentación Des. A.C., Hermosillo, Mexico
Michael Criscitiello , Texas A&M University, College Station, TX
Scott Dindot , Department of Veterinary Pathobiology, Texas A & M University, College Station, TX
Alejandro Sanchez-Flores , UNAM, Cuernavaca, Morelos, Mexico
Karina Garcia-Orozco , CIAD Centro de Inv. en Alimentación Des. A.C., Mexico
Alonso Lopez-Zavala , CIAD Centro de Inv. en Alimentación Des. A.C., Mexico
Eduardo Guevara-Hernandez , CIAD Centro de Inv. en Alimentación Des. A.C., Mexico
J. Salvador Carrasco-Miranda , CIAD Centro de Inv. en Alimentación Des. A.C., Mexico
Based on a recent RNAseq transcriptome, we have surveyed the amino acid deduced sequences for potential antiviral targets. Our research program is focused on nucleotide metabolism that is required for synthesis of the DNA-double stranded circular white spot syndrome virus. Previous availavility of ESTs allowed us to get partial sequences by tblastn required obtaining the UTRs by RACE. Nowadays the availability of thousands of sequences makes possible to pursue recombinant expression of proteins in complete pathways. We will discuss the RNAseq amino acid sequences in terms of pathways analyzed by Gene Ontology and KEGG classifications. Also, potential candidates for 3-dimensional structure determination by X-diffraction is presented as a tool for contributing towards structure-function of antiviral targets in this important aquaculture species.
Back to: Genome Mapping, Tagging & Characterization: Aquaculture
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