Ocean acidification and hypoxia (OAH) are accelerating rapidly, with implications for the health and productivity of coastal and ocean ecosystems and the communities and industries that depend on them. As scientific understanding of the drivers and impacts of OAH grows, countries, states, tribes, and local governments are recognizing the urgent need to take action. From assessing risks to fisheries and aquaculture, developing water and air quality management targets, advancing monitoring networks and technology, and restoring and protecting living systems for their blue carbon services, the tools within the OAH action toolbox continue to expand. This session will feature case studies from across U.S. states and internationally where science is being used to inform management and policy action to reduce drivers, manage impacts, and develop solutions to address OAH, including “no regrets” measures to support resilient ecosystems and coastal economies. We encourage submissions that highlight examples where scientists, governments, non-governmental organizations, and industries are working collaboratively to advance OAH mitigation, adaptation, and resiliency, which can serve as exportable models for other regions and jurisdictions.