162 Model Based Integrated Design of Pharmaceutical Drug Product Processes


Description:
session seeks contributions where modeling-aided approaches as well as optimization techniques have been applied for decision making in the design and development of pharmaceutical intermediates, and/or drug products. Modeling research using deterministic models derived from fundamental principles are all in scope for this session. Authors are encouraged to highlight integration to upstream and downstream operations as well as Quality by Design considerations.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)


Chair:
Brendon G. Ricart
Senior Chemical Engineer
Merck & Co., Inc.
WP78-304
West Point, PA
19486
Email: brendon_ricart@merck.com

Co-Chair:
Nima Yazdanpanah
Massachusetts Institute of Technology
Department of Chemical Engineering
Cambridge, MA
Email: nima@mit.edu


Papers:
162a
A Compartmentalized, Numerical Model of Continuous Blending
Pongpumin Bunchatheeravate, Vertex Pharmaceuticals; Joseph W. Bullard, Vertex Pharmaceuticals; Steven Dale, Vertex Pharmaceuticals; Greg Connelly, Vertex Pharmaceuticals; Marcus O'Mahony, Vertex Pharmaceuticals
162b
Impact of Raw Material and Blend Properties on the Screw Feeding, Continuous Blending and Tableting Unit Operation of an Integrated Continuous Direct Compression Platform
Bernd Van Snick, Janssen pharmaceutica; Valérie Vanhoorne, Ghent University; Maxim Verstraeten, Ghent University; Jens Dhondt, Ghent University; Giustino Di Pretoro, Janssen pharmaceutica; Thomas De Beer, Ghent University; Chris Vervaet, Ghent University
162c
Feeder Characterization and Model Development Accounting for Incoming Material Properties
M. Sebastian Escotet-Espinoza, Rutgers, The State University of New Jersey; Glinka Cathy Pereira, Rutgers, The State University of New Jersey; Andrés D. Román-Ospino, Rutgers University; Fernando Muzzio, Rutgers, The State University of New Jersey; Marianthi Ierapetritou, Rutgers, The State University of New Jersey
162d
Disintegration and Dissolution Modeling for Accelerated Drug Product Process Development
Pedro Valente, Hovione FarmaCiência SA; Slavomira Doktorovova, Hovione FarmaCiência SA; Nuno Enes, Mechanical Engineering Department, Instituto Superior Tecnico, University of Lisbon; João Henriques, Hovione FarmaCiência SA; Paulo Lino, Hovione FarmaCiência SA; Inês Lopes, FCT-UNL; Nuno Neves, Hovione FarmaCiência SA; Mafalda Paiva, Hovione FarmaCiência SA; Tiago Porfirio, Instituto Superior Tecnico, University of Lisbon; João Vicente, Hovione FarmaCiência SA; Márcio Temtem, Hovione FarmaCiência SA
162e
Modeling of Flow and Drying of Aqueous Polymer Coatings on Porous Pharmaceutical Tablets
Charalampos Christodoulou, University College London; Eva Sørensen, University College London; Salvador García-Muñoz, Eli Lilly and Company; Luca Mazzei, University College London
162f
Modelling and Simulation Efforts in Scale up and Characterisation of Semi-Solid Dosage Forms
Saurav S. Rath, Dr Reddys Laboratories; Birendra K. David, Dr Reddys Laboratories; RaviChandra Palaparthi, Dr Reddys Laboratories
162g
Dissolution Kinetics Modelling of a BCS Class II Active Pharmaceutical Ingredient
Yuan Gao, University College Dublin; Brian Glennon, University College Dublin; Yunliang He, University College Dublin; Guangyang Hou, APC Ltd; Philip Donnellan, University College Dublin
Abstract Submissions Closed
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